New research has revealed a connection between ancient viral DNA embedded in the human genome and the genetic risk for two major diseases that affect the central nervous system.
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NIHR Maudsley BRC at 23 Oct 2024
The new GenoPred pipeline enables researchers to easily calculate an individual’s likelihood of different health-related outcomes, such as disease and disorders or response to treatment, based on their genetics.
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NIHR Maudsley BRC at 3 Jun 2024
Around 8% of human DNA is made up of genetic sequences acquired from ancient viruses. These sequences, known as human endogenous retroviruses (or Hervs), date back hundreds of thousands to millions of years – with some even predating the emergence of Homo sapiens.
This article is written by Rodrigo Duarte, Research Fellow, King's College London; Douglas Nixon, Professor of Immunology in Medicine, Cornell University, and Timothy Powell, Senior lecturer, King's College London. It is republished from The Conversation under a Creative Commons license.
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NIHR Maudsley BRC at 28 May 2024
New research led by King’s College London has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.
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NIHR Maudsley BRC at 22 May 2024
Professor Richard Emsley is the NIHR Maudsley BRC's Theme Lead in Trials, Prediction and Genomics, and was recently appointed the role of Interim Academic Director of the King’s Clinical Trials Unit and lead of a new NIHR Research Services Support hub. He specialises in improving the delivery of clinical trials in mental health, supported by the NIHR and with partners at King's College London's as well as across the country. In this interview he provides some insights into his work in this area.
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NIHR Maudsley BRC at 24 Jan 2024